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Effect of Gongronema latifolium on gastric emptying in healthy dogs
Sylvester O Ogbu,Kenneth K Agwu,Isaac U Asuzu
World Journal of Gastroenterology , 2013, DOI: 10.3748/wjg.v19.i6.897
Abstract: AIM: To investigate sonographically the effect of Gonogronema latifolium (G. latifolium) on gastric emptying of semi-solid meals in healthy dogs. METHODS: In a randomized, placebo-controlled experiment, twenty-five clinically healthy dogs were randomly allotted into five groups of five dogs in each group. The placebo group served as the control, and the low, moderate and high dose groups ingested the methanolic leaf extract of G. latifolium in capsules at 100 mg/kg, 250 mg/kg and 500 mg/kg, respectively, while the prokinetic group ingested 0.5 mg/kg capsules of metoclopramide. After a 12-h fast, each group ingested its treatment capsules 30 min before the administration of a test meal. Measurements of gastric emptying and blood glucose levels were obtained 30 min before and immediately after the ingestion of the test meal and thereafter every 15 min for 4 h. This was followed by further measurements every 30 min for another 2 h. RESULTS: The gastric emptying times of the placebo, low dose, moderate dose, high dose and prokinetic dose groups were 127.0 ± 8.2 min, 135.5 ± 3.7 min, 155.5 ± 3.9 min, 198.0 ± 5.3 min and 59.0 ± 2.5 min, respectively. Gastric emptying times of the moderate and high dose groups were significantly slower than in the placebo control group (155.5 ± 3.9 min, 198.0 ± 5.3 min vs 127.0 ± 8.2 min, P = 0.000). No significant difference in gastric emptying between the low dose and placebo control groups was noted (135.5 ± 3.7 min vs 127.0 ± 8.2 min, P = 0.072). Gastric emptying of the prokinetic group was significantly faster than that of the control group (59.0 ± 2.5 min vs 127.0 ± 8.2 min, P = 0.000). The hypoglycaemic effect of G. latifolium and gastric emptying were inversely related (r = -0.95, P = 0.000). CONCLUSION: G. latifolium delays gastric emptying and lowers postprandial blood glucose in healthy dogs. It reduces the postprandial blood glucose by delaying gastric emptying.
Chemical Composition of the Marc of a Wild Tropical Plant Tacca involucrata (Schumach and Thonn, 1827)  [PDF]
Joel Aondohulugh Bosha, Aruh Ottoh Anaga, Isaac Uzoma Asuzu
Food and Nutrition Sciences (FNS) , 2015, DOI: 10.4236/fns.2015.61014
Abstract: Tacca involucrata (Batflower or Polynesian arrowroot) tubers are a stable food in tropics where it occurs. In central Nigeria, it is processed locally after digging it from the ground by peeling with sharp sand, grating and soaking in fresh water after which it is filtered and the filtrate is dried and is cooked with other ingredients. The marc, said to be bitter, is usually discarded by deep burial as it is considered poisonous to livestock and humans. All parts of the plant are used in folk medicine to treat various diseases. The aim of this work was to analyze quantitatively the phytochemical, elemental, vitamin and proximate composition of the marc of the tubers with a view of assessing its pharmacological and nutritional potentials. The marc was obtained from Jandeikyura Village in Wukari LGA of Taraba State, Nigeria, and was extracted with 80% methanol for 72 hr to give a yield of 10.1% w/w and was whitish in colour. Phytochemical analysis showed the presence of reducing sugars, tannins, flavonoids, steroids, glycosides and hydrogen cyanide at 195.65 ± 0.5, 3.44 ± 0.2, 1.29 ± 0.5, 0.83 ± 0.4, 1.36 ± 1.0 and 0.00985 ± 0.3 (mg/100g), respectively. The elemental analysis showed the presence of potassium, sodium, magnesium, selenium, manganese, vanadium and some heavy metals like lead, aluminium, arsenic and mercury at 36.45 ± 0.1, 44.04 ± 0.1, 1.52 ± 0.2, 0.80 ± 0.9, 0.52 ± 0.7, 0.27 ± 0.7, 0.07 ± 0.6, 0.008 ± 0.05, 0.085 ± 0.6 and 0.026 ± 0.6 (mg/100g), respectively. Vitamin analysis showed the presence of vitamins A, B1, B2, B3, C and E in various amount as 2.26 ± 0.8 μg, 0.83 ± 0.8 mg/100g, 0.58 ± 0.4 mg/100g, 0.33 ± 0.6 mg/100g, 9.80 ± 0.4 mg/100g and 6.86 ± 0.9 mg/100g, respectively. The proximate analysis showed the marc to contain moisture, ash, fats, fibre, crude protein and carbohydrate in the range of 10.83% ± 0.3%, 1.93% ± 0.6%, 1.06% ± 0.5%, 4.42% ± 0.4%, 6.12% ± 0.6% and 86.07% ± 0.3%, respectively. This shows that despite the presence of hydrogen cyanide and some heavy metals in traces amount which are considered poisonous to livestock and humans, the marc contains some elements, vitamins, phytochemical and nutrients which are pharmacologically and nutritionally important.
Hepatoprotective and antioxidant activities of Pterocarpus santalinoides methanol leaf extract
Aruh Ottah Anaga,Isaac Uzoma Asuzu,John Ikechukwu Ihedioha,Thelma Ebele Ihedioha
- , 2019, DOI: 10.5897/AJPP2019.5090
Abstract:
PREVALENCE AND DETERMINANTS OF STUNTING AMONG PRIMARY SCHOOL CHILDREN IN RURAL AND URBAN COMMUNITIES IN OBAFEMI OWODE LOCAL GOVERNMENT AREA, SOUTHWESTERN NIGERIA
K.O. Odebunmi,M.C. Asuzu,T.A. Obembe,W.U. Adenuga
- , 2017,
Abstract: Studies on stunting in children have largely focused on the underfive, establishing it as a strong predictor of mortality in these children. Few studies have documented the prevalence or determinants of stunting among school children in southwestern Nigeria. The aim of the study was to determine the prevalence and predictors of stunting among selected primary school children in rural and urban communities of Obafemi Owode Local Government Area, Ogun State
Prevalence and determinants of stunting among primary school children in rural and urban communities in Obafemi Owode Local Government Area, Southwestern Nigeria
K.O. Odebunmi,M.C. Asuzu,T.A. Obembe,W.U. Adenuga
- , 2017,
Abstract: Background: Studies on stunting in children have largely focused on the underfive, establishing it as a strong predictor of mortality in these children. Few studies have documented the prevalence or determinants of stunting among school children in southwestern Nigeria. The aim of the study was to determine the prevalence and predictors of stunting among selected primary school children in rural and urban communities of Obafemi Owode Local Government Area, Ogun State.
Commentary: The necessity for a health systems reform in Nigeria
MC Asuzu
Journal of Community Medicine and Primary Health Care , 2004,
Abstract: No Abstract Available
Optical and Structural Properties of Chemical Bath Deposited Cadmium Sulphur Selenide (CdS1–xSex (0 ≤ x ≤ 1)) Thin Films  [PDF]
David U. Ngbiche, Isaac Nkrumah, Francis K. Ampong, Mark Paal, Robert K. Nkum, Francis K. Boakye
Open Journal of Applied Sciences (OJAppS) , 2019, DOI: 10.4236/ojapps.2019.911064
Abstract: The tuneable band gap property of Cadmium-sulphur-selenide (CdS1–xSex) thin film makes it an appropriate material for a wide range of optoelec-tronic applications and this has aroused a lot of interest. In this paper, we report the study of Cadmium-sulphur-selenide (CdS1–xSex) thin films, successfully grown on commercial glass slide substrate by the chemical bath deposition technique. The effect of selenium content (x value) on the structural, and some optical properties have been studied. The bath solution contained cadmium acetate dehydrate [Cd(CH3COO)2·2H2O], so-dium selenosulphate [Na2SeSO3] and thiourea [CS(NH2)2] were used as the sources of Cd2+, Se2 and S2+, respectively. Tartaric acid (C4H6O6) was used as a complexing agent. The pH of the solution was adjusted to 12 by drop-wise addition of ammonia. The bath temperature was kept at 90°C for a deposition time of 1 hour. Post deposition annealing processes of the thin films were performed in a furnace at a temperature of 400°C for two hours. Both as-deposited and annealed films were characterised by Powder X-Ray Diffraction, Scanning Electron Microscopy, UV-Visible Optical Absorption Spectroscopy and Energy Dispersive X-Ray Analysis. Optical absorption data analysis indicates that direct allowed transitions occur in the films. The band gap of the as-deposited CdS1–xSex decreased linearly from 2.34 eV to 1.48 eV, with increasing selenium content, and in the annealed samples, decreased from 1.84 eV to 1.36 eV. X-ray diffrac-tion measurements revealed, that pure CdS, and CdSe had mixed hexago-nal and cubic phases. All the remaining ternary compounds were com-posed of cubic CdS and hexagonal CdSe phases. The annealed samples showed well defined and more intense peaks, suggesting an improvement in crystallinity. The average grain size increased slightly with increasing selenium content. SEM micrographs showed that the films were compact with a smooth texture and good coverage across the entire area of the substrate.
Condom use amongst out of school youths in a local government area in Nigeria
AO Adebiyi, MC Asuzu
African Health Sciences , 2009,
Abstract: Background: Reported low condom use amongst out of school requires studying the context in which condom use occurs. Methods: A cross sectional study of 350 out-of-school youth aged 15-24 years in a local government area of Nigeria was enrolled using cluster sampling. Results: Those who had ever had sexual intercourse were 74.9%. Of these, 56.5% used no protection while 29.0% used condoms. Up to 78.6% have had sex within the preceding 12 months with 38.9% condom use. The commonest reason for non-condom use was that it reduces sexual enjoyment. Those who believed a single unprotected sexual exposure may result in HIV infection reported more condom use than those who believed otherwise (42% vs 27.2%, P<0.05). Those who had prior discussion with their partners on HIV/AIDS reported more condom use compared to those who had not (50% vs 25%, P<0.05). Also, those who had sexual intercourse occurring as a spontaneous event reported less condom use compared to those who have previously discussed about the possibility of having sex (68.0% vs 51.8%, P<0.05). Conclusion: Condom use is likely to occur within relationships where opportunity exists for discussion on sexual matters. Thus, further studies are needed on communication and condom use within sexual partnerships.
Ocular findings seen among the staff of an institution in Lagos, Nigeria
AO Ashaye, MC Asuzu
West African Journal of Medicine , 2005,
Abstract: Background:The degree to which ocular morbidity affects workers productivity in the developing countries has not been studied adequately. A federal government research institute based in Lagos introduced an annual health screen for all its workers, which included eye tests. This provided an opportunity to study the pattern of ocular conditions among workers who were 30 years and above, and to determine the effect of eye diseases on the workers productivity. Study design: Detailed eye examination including refraction, was done on every respondent at the institution\'s clinic by an ophthalmologist. A questionnaire on ocular health status and occupational history was administered independently by an ophthalmic nurse. Sickness absenteeism, use of the clinic were obtained from clinic records, and the results were analysed. Results: The common ocular conditions were uncorrected or poorly corrected refractive error, uncorrected or poorly corrected presbyopia and allergic conjunctivitis. Glaucoma, maculopathy and optic atrophy were causes of severe visual impairment or blindness in 1.9% of the subjects. Absenteeism and clinic use were more common in subjects with ocular morbidity than those with non-ocular morbidity. Subjects with ocular morbidity had more illnesses, absenteeism and used the clinic more. Conclusion: Ocular problems which reduce worker\'s productivity are prevalent among the staff of the institution studied. They are mostly unrecognised.
The anthelmintic effects of Buchholzia coriacea seed
NE Nweze, IU Asuzu
Nigerian Veterinary Journal , 2006,
Abstract: No s. Nigerian Veterinary Journal Vol.27(2) 2006: pp.60-65
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